Nanomaterials for Intracellular pH Sensing and Imaging

Intracellular pH is a vital parameter that precisely controls cell functionalities, activities and cellular events. Abnormal intracellular pH is always closely related to the healthy status of cells, which is further translated into pathological changes in a macro perspective. Because of the highly compartmentalized structure inside cells, the pH in each compartment can be precisely tuned to optimize certain cellular functionality, and biological reactions in these region occur at optimum condition. Thus, it is important to design sensors that can precisely measure pH in these regions, and sensors much have good biocompatibility, physical stability, high sensitivity, wide measurement range, as well as fast response, to fulfill the requirements for intracellular pH measurement. In this chapter, we will start from illustrating the importance of measuring intracellular pH, and further discuss how to design optical nanosensors for sensing and imaging intracellular pH. The state of the art technology in intracellular pH sensing and imaging will be reviewed, nanomaterials that are used for constructing intracellular pH sensors will be summarized and the perspective of nanomaterials for intracellular pH sensing and imaging will be given at the end.

Table of Content

1. Synthesis, Characterization, Properties, and Application Development of Novel Nanomaterials
2. Novel Nanomaterials for Protein Analysis
3. Magnetic nanomaterials for magnetic bioanalysis
4. Functionalization of Gold nanoparticles with DNA for Bioanalytical Application
5. Surface Engineering of Carbon Nanodots (CDs) for Biomedical applications
6. Novel Nano Materials for the Fabrication of Electrochemiluminescent Sensors
7. Fluorescent Graphene Quantum Dots for the Determination of Metal Ions
8. Nanomaterials for Intracellular pH Sensing and Imaging
9. Nanotechnology of Metal Oxide-based Gas Sensors for Air Pollution Control
10. Applications and Prospects of Nanomaterials with High Photocatalytic Activity on Air Purification
11. Plasmonic Metallic Nanostructures as Optical Sensors for Environmental Pollutants
12. Application of Novel Nanomaterials for Chemo- and Biosensing of Algal Toxins in Shellfish and Water
13. Photothermal Effect of nanomaterials for Efficient Energy Applications
14. Nanomaterials with Different Dimensions for Electrocatalysis